48 papers
This retrospective study of 58 obstetric ICU admissions at a tertiary urban center reveals that 81% of patients were non-Hispanic Black and 91% were publicly insured, highlighting local disparities that align with national trends of elevated severe maternal morbidity and mortality among Black women and those with Medicaid coverage.
A retrospective study of nearly 100,000 pregnancies in the U.S. Midwest from 2019 to 2024 reveals that while prenatal depression screening rates increased overall, a significant and widening disparity emerged by 2024, with non-English speaking patients experiencing substantially lower screening uptake compared to English speakers.
This national population-based study of 477,693 deliveries externally validated a cumulative risk score derived from single-center data, confirming its monotonic dose-response relationship with both vaginal birth after cesarean success and neonatal morbidity to support individualized counseling for trial of labor after cesarean.
This study protocol outlines a double-blind, randomized controlled trial in Lagos, Nigeria, designed to evaluate whether daily oral N-acetylcysteine (NAC) can delay the progression of early-onset preeclampsia to severe disease compared to a placebo, potentially offering a safe and affordable intervention for resource-constrained settings.
This population-based study of over 41 million U.S. births from 2014 to 2024 reveals that racial and ethnic disparities in cesarean delivery rates persist independently of insurance status, with non-Hispanic Black women facing the highest risks across all coverage types and the most significant absolute disparities observed among the uninsured.
This two-sample Mendelian randomization study with maternal-fetal effect decomposition provides robust evidence that genetic liability to endometriosis causally increases the risk of placenta praevia through maternal pathways, while suggesting that previously observed associations with other adverse pregnancy outcomes are likely driven by confounding factors rather than direct causality.
This study utilizes an in vitro embryo-endometrium co-culture model to demonstrate that a hormonally primed endometrial environment not only facilitates blastoid attachment but also significantly amplifies the production and bioactivity of hyperglycosylated human chorionic gonadotropin (hCG), thereby revealing a critical reciprocal endocrine signaling mechanism during early human implantation.
This mixed-method study of 300 undergraduates at Osun State University reveals that students possess low knowledge and predominantly negative attitudes toward male infertility, which are significantly influenced by academic level, faculty, and formal education, highlighting the urgent need for gender-inclusive health education to address cultural misconceptions.
This qualitative study reveals a significant disconnect between endometriosis patients and healthcare professionals regarding the definition of treatment efficacy and communication quality, highlighting the need for improved shared decision-making to address mutual mental burdens and information deficits.
This population-based analysis of 5.8 million US births externally validates a risk-stratified delivery timing model, demonstrating that individualized management strategies—specifically induction at 39 weeks for high-risk patients and expectant management until 41–42 weeks for low-risk patients—can effectively reduce NTSV cesarean rates.
This Belgian nationwide study reveals that while surgical complications during pregnancy following bariatric surgery are rare and predominantly involve internal herniation after Roux-en-Y gastric bypass, prompt surgical intervention ensures maternal survival but frequently leads to significant obstetric risks, including preterm birth and emergency caesarean sections.
This study utilizes the Swedish BASIC cohort to identify DNA methylation signatures across the peripartum period that not only offer mechanistic insights into perinatal suicidal ideation but also enable the prediction of post-partum risk with high accuracy, particularly when combined with depression severity.
This nested case-control study of over 5,000 pregnant women found that maternal APOL1 risk alleles do not independently increase the risk of preeclampsia or related adverse pregnancy outcomes, even among women of Black ethnicity or those with pan-African genetic ancestry.
In a randomized, double-blind, placebo-controlled trial involving 40 women, oral L-ergothioneine supplementation (120 mg/day) significantly and progressively reduced primary dysmenorrhea pain and associated symptoms over three menstrual cycles without adverse events, suggesting a cytoprotective mechanism independent of classical inflammatory pathways.
This study developed and validated a 55-gene hypoxia-associated signature that effectively stratifies uterine cervical cancer patients by identifying those with advanced disease features and significantly worse survival outcomes, suggesting its potential utility for guiding hypoxia-targeted therapies.
This longitudinal study of over 5,700 pregnant women across five low- and middle-income countries reveals that pregnancy loss remains a significant public health challenge with a cumulative risk of 103 per 1,000 pregnancies after 8 weeks, peaking in early gestation and among women over 35, while highlighting that conventional estimates often underestimate rates due to delayed enrollment.
This prospective study of 667 women demonstrates that obstetric complications increase the risk of childbirth-related posttraumatic stress disorder symptoms at two months postpartum indirectly by first heightening acute peritraumatic distress and early postpartum trauma symptoms, rather than through a direct effect or via depression.
A six-month course of dienogest therapy significantly reduced endometrioma size, pelvic pain, and CA-125 levels in women with endometriosis, suggesting it is an effective non-surgical treatment option for managing symptoms and preserving ovarian reserve.
Secondary outcomes from the ACT 2 randomized controlled trial indicate that adjuvant intravaginal 5-fluorouracil cream following LEEP significantly improves histologic regression of cervical precancer in women living with HIV, particularly among those with positive LEEP margins, although it did not significantly enhance high-risk HPV clearance compared to placebo.
This study quantifies the contribution of maternal lead exposure to preeclampsia risk in sub-Saharan Africa, finding that while common exposure levels yield modest risk increases, severe environmental contamination could substantially elevate disease burden, thereby supporting the integration of lead prevention into maternal health strategies.